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August 1, 2024Open Access

Figure S5 from Venetoclax Induces BCL-2–Dependent Treg to TH17 Plasticity to Enhance the Antitumor Efficacy of Anti–PD-1 Checkpoint Blockade

Rosy Liao Jocelyn Y. Hsu Nada S. Aboelella Joshua A. McKeever Anika Thomas-Toth Andrew S. Koh James L. LaBelle

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Abstract

Supplementary Figure S5. Differential accessibility of key transcription factors that have shown to play a role in Treg plasticity represented in Tregs isolated from vehicle and venetoclaxtreated animals. Specifically, increased accessibility of RORγt, BATF, and IRF4 are crucial for Treg to TH17 plasticity.

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Liao et al. (2024) studied this question.

synapsesocial.com/papers/68e5e0e0b6db643587575033 https://doi.org/10.1158/2326-6066.26422649.v1

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S7 from Venetoclax Induces BCL-2–Dependent Treg to T<sub>H</sub>17 Plasticity to Enhance the Antitumor Efficacy of Anti–PD-1 Checkpoint Blockade2024
2Figure S4 from Venetoclax Induces BCL-2–Dependent Treg to T<sub>H</sub>17 Plasticity to Enhance the Antitumor Efficacy of Anti–PD-1 Checkpoint Blockade2024
3Figure S8 from Venetoclax Induces BCL-2–Dependent Treg to T<sub>H</sub>17 Plasticity to Enhance the Antitumor Efficacy of Anti–PD-1 Checkpoint Blockade2024
4Figure S6 from Venetoclax Induces BCL-2–Dependent Treg to T<sub>H</sub>17 Plasticity to Enhance the Antitumor Efficacy of Anti–PD-1 Checkpoint Blockade2024
5Figure S3 from Venetoclax Induces BCL-2–Dependent Treg to T<sub>H</sub>17 Plasticity to Enhance the Antitumor Efficacy of Anti–PD-1 Checkpoint Blockade2024
6Figure S2 from Venetoclax Induces BCL-2–Dependent Treg to T<sub>H</sub>17 Plasticity to Enhance the Antitumor Efficacy of Anti–PD-1 Checkpoint Blockade2024
7Figure S10 from Venetoclax Induces BCL-2–Dependent Treg to T<sub>H</sub>17 Plasticity to Enhance the Antitumor Efficacy of Anti–PD-1 Checkpoint Blockade2024
8Data from Venetoclax Induces BCL-2–Dependent Treg to T<sub>H</sub>17 Plasticity to Enhance the Antitumor Efficacy of Anti–PD-1 Checkpoint Blockade2024