IL-10 -592 C/A polymorphism association with hemorrhagic stroke/aneurysm and their risk factors

Stroke is one of the leading causes of death worldwide. Hemorrhagic strokes (HS) present higher mortality than ischemic stroke (IS) and promote disability and dependency on trivial activities in most patients. Although unclear for HS, inflammatory mediators appear to promote IS onset that anti-inflammatory cytokines, such as IL-10, could mitigate. Polymorphisms in cytokine locus can affect its expression, especially in regulation regions, or affect protein's structure and, consequently, its biological role, impacting its availability or performance and promoting pathogenesis. In this case-control study, we analyze IL-10 -592 C/A (rs1800872) polymorphism association with HS by investigating 162 participants - 81 patients with HS, aneurysm, or both and 81 healthy controls - from Federal District, Brazil. We also evaluate this polymorphism association with known risk factors for strokes - high blood pressure, smoking, alcoholism, and diabetes. Herein, we found no association between the IL-10 -592 C/A polymorphism and HS, nor the risk factors examined.