Serum level of IL-10 and IL-10-1082G/A polymorphism are associated with the risk of ischemic stroke: A meta-analysis

Abstract BACKGROUND Stroke is one of the leading causes of disability and mortality among adults worldwide. The aim of the study was to confirm the relationship of serum interleukin-10 (IL-10) and its gene polymorphism with the risk of ischemic stroke (IS). METHODS PubMed and China Wanfang database were systematically searched up to September 2, 2019. Studies illustrating on the association between serum IL-10 or IL-10-1082G/A, IL-10-819C/T, IL-10- 592C/A polymorphisms and IS susceptibility were included in this study. Newcastle–Ottawa scale was used to assess the study quality. RevMan 5.3 was used for statistical analysis. RESULTS: Seventeen case-control studies were included in this meta-analysis which provides 3754 patients with IS and 5064 controls. Combined analysis indicated that patients with IS had lower serum level of IL-10 (Mean difference [MD]: -4.25; 95% confidence interval [CI]: -6.14 to -2.36, p<0.0001). An association was identified between IL-10-1082G/A polymorphism and the risk of IS, but no association was found between polymorphism of IL-10-819C/T or IL-10- 592C/A and the risk of IS when all ethnic groups were considered together. For IL-10-1082G/A polymorphism, individuals with AA-genotype might have an increased risk of IS among Chinese Han population while no such correlation was observed in other ethnic group. CONCLUSION This meta-analysis suggested that low serum level of IL-10 and IL-10-1082G/A polymorphism may be associated with the risk of IS. More clinical studies should be conducted to confirm the relationship between serum IL-10 level and the risk of IS in all ethnic groups.