Key result
IL-10-1082 AA genotype linked to ~27% lower odds of rheumatic heart disease.
Why the study?
There was no systematic study to verify the correlation between IL-10-1082G/A single nucleotide polymorphism and rheumatic heart disease.
Is the single nucleotide polymorphism of IL-10-1082G/A associated with rheumatic heart disease?
Meta-Analysis (n=820)
Is the single nucleotide polymorphism of IL-10-1082G/A associated with rheumatic heart disease?
This meta-analysis found no definitive overall correlation between the IL-10-1082G/A gene polymorphism and rheumatic heart disease, though a potential association when AA is a recessive gene requires further study.
// Weiran Dai 1 , Ziliang Ye 1, 2 , Haili Lu 2 , Qiang Su 1 , Hui Li 3 and Lang Li 1 1 Department of Cardiology, the First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning, Guangxi, China 2 Guangxi Medical University, Nanning, Guangxi, China 3 Department of Infectious Diseases, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China Correspondence to: Lang Li, email: drrlilang@126.com Keywords: IL-10-1082G/A; single nucleotide polymorphism; rheumatic heart disease; correlation; meta-analysis Received: July 10, 2017 Accepted: November 09, 2017 Published: January 03, 2018 ABSTRACT Background: The results showed that there was a certain correlation between the single nucleotide polymorphism of IL-10-1082G/A and rheumatic heart disease, but there was no systematic study to verify this conclusion. Aims: Systematic review of the association between single nucleotide polymorphism of IL-10-1082G/A locus and rheumatic heart disease. Materials and Methods: Computer retrieval PubMed, EMbase, Cochrane Library, CBM, CNKI, VIP and Data WanFang, the retrieval time limit from inception to June 2017. A case control study of single nucleotide polymorphisms and rheumatic heart disease in patients with rheumatic heart disease in the IL-10-1082G/A was collected. Two researchers independently screened the literature, extracted data and evaluated the risk of bias in the study, and using RevMan5.3 software for data analysis. Results: A total of 3 case control studies were included, including 318 patients with rheumatic heart disease and 502 controls. Meta-analysis showed that there was no correlation between IL-10-1082G/A gene polymorphism and rheumatic heart disease [AA+AG VS GG: OR = 0.62, 95% CI (0.28, 1.39), P = 0.25; AA VS AG+GG: OR = 0.73, 95% CI (0.54, 1.00), P = 0.05; AA VS GG: OR = 0.70, 95% CI(0.47, 1.05), P = 0.08; AG VS GG: OR = 0.65, 95% CI (0.22, 1.92), P = 0.43; A VS G: OR = 0.87, 95% CI (0.71, 1.06), P = 0.17]. Conclusions: When AA is a recessive gene, the single nucleotide polymorphism of IL-10-1082G/A is associated with the presence of rheumatic heart disease. Due to the limitations of the quantity and quality of the included literatures, the further research results were still needed.
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Dai et al. (2018) conducted a meta-analysis in Rheumatic heart disease (n=820). IL-10-1082G/A gene polymorphism (AA genotype) vs. AG+GG genotypes was evaluated on Presence of rheumatic heart disease (OR 0.73, 95% CI 0.54-1.00, p=0.05). The IL-10-1082G/A gene polymorphism (AA vs AG+GG) was associated with the presence of rheumatic heart disease (OR 0.73; 95% CI 0.54-1.00; P=0.05).
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