December 31, 2002British journal of rheumatologyOpen Access

Rheumatoid arthritis susceptibility and interleukin 10: a study of two ethnically diverse populations

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Why the study?

Is the IL10.R2 allele associated with rheumatoid arthritis susceptibility in UK Caucasian and South African populations?

Population

186 UK Caucasians and 138 South Africans of Zulu or Sotho origin with rheumatoid arthritis, plus 296…

Comparison

IL10.R genotype assessment vs Controls without rheumatoid arthritis from the…

Design

Case-control

Authors

KMK. MackayMayo Clinic

Discussion

Member takes

Implication

No association with RA susceptibility in these populations; leaves open ethnic or mechanistic effects and should not yet alter genetic risk models.

Structured PICO

Is the IL10.R2 allele associated with rheumatoid arthritis susceptibility in UK Caucasian and South African populations?

Population

186 UK Caucasians and 138 South Africans of Zulu or Sotho origin with rheumatoid arthritis (fulfilling 1987 ACR criteria), plus 296 Caucasian and 73 South African controls. Caucasian patients had relatively severe disease (75 with RA vasculitis, 22 with Felty's syndrome, 89 with joint replacement within 15 years).

Intervention

IL10.R genotype assessment (specifically IL10.R2 and IL10.R3 alleles)

Comparator

Controls without rheumatoid arthritis from the same ethnic populations

Outcome

Association between the IL10.R2 allele and rheumatoid arthritissurrogate

This study found no association between IL10.R alleles and rheumatoid arthritis susceptibility in UK Caucasian or South African populations, challenging previous reports of such an association.

Limitations

The relatively high frequency of IL10.R2 in the South African population (0.78) would have reduced the power to detect an association with RA.

Cite This Study

K. Mackay (2002) studied this question.

synapsesocial.com/papers/6a72d05479560908ab3dadc6 https://doi.org/10.1093/rheumatology/keg054

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Implication

No association with RA susceptibility in these populations; leaves open ethnic or mechanistic effects and should not yet alter genetic risk models.

Rheumatoid arthritis susceptibility and interleukin 10: a study of two ethnically diverse populations

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Rheumatoid arthritis susceptibility and interleukin 10: a study of two ethnically diverse populations

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider