Key result
IL-10 promoter polymorphism frequencies show no difference between rheumatoid arthritis, Felty's syndrome, and controls.
Why the study?
Are IL-10 promoter polymorphisms associated with the development of rheumatoid arthritis or Felty's syndrome?
Case-Control (n=456)
Are IL-10 promoter polymorphisms associated with the development of rheumatoid arthritis or Felty's syndrome?
IL-10 promoter polymorphisms are not associated with the development of rheumatoid arthritis or Felty's syndrome.
IL-10 promoter polymorphisms need not inform RA or Felty's risk assessment; leaves open contributions from other genetic or environmental factors.
OBJECTIVE: To examine whether promoter polymorphisms associated with variation in interleukin-10 (IL-10) production are relevant to the development of rheumatoid arthritis (RA) or Felty's syndrome (FS). METHODS: DNA was obtained from 44 FS patients, 117 RA patients and 295 controls. The promoter region between -533 and - 1120 was amplified by polymerase chain reaction, and polymorphisms detected by restriction enzyme digest or sequence-specific oligonucleotide probing. RESULTS: We found no significant difference in allele or haplotype frequencies between the groups. CONCLUSION: There is no association between FS or RA and these recently identified IL-10 promoter polymorphisms. Other genetic or environmental factors could explain the alterations in IL-10 levels seen in these conditions.
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Coakley et al. (1998) conducted a case-control in Rheumatoid arthritis and Felty's syndrome (n=456). Interleukin-10 (IL-10) promoter polymorphisms vs. Controls was evaluated on Allele or haplotype frequencies. Interleukin-10 promoter polymorphisms showed no significant difference in allele or haplotype frequencies between patients with rheumatoid arthritis, Felty's syndrome, and controls.
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