AB009. Distinct clinical profiles and treatment outcomes in invasive pituitary adenoma and Crooke cell tumor: a comparative case study

Pituitary adenomas, particularly invasive pituitary adenomas and Crooke cell tumors, represent significant neuroendocrine tumors with diverse clinical and pathological profiles. Invasive pituitary adenomas are known for their aggressive growth and potential to invade surrounding structures, leading to notable endocrine and neurological complications. Crooke cell tumors, a rare variant of corticotroph adenomas, are characterized by Crooke cells-basophilic cells with cytoplasmic changes due to prolonged glucocorticoid exposure. Although these tumors have aggressive histological features, their clinical behavior can vary widely, often determined by their proliferative index, such as Ki-67. This case report presents two patients with pituitary adenomas, highlighting the contrasting clinical courses, management strategies, and pathological findings.