Comparison of Mydriatic Effect Between Tropicamide and Phenylephrine With Flurbiprofen vs Tropicamide and Phenylephrine in Cataract Patients.

Objective: The main objective is to evaluate the effectiveness of the new combination of two drugs i.e. Tropicamide, Phenylephrine with Flurbiprofen, and tropicamide with phenylephrine to achieve maximal pupil dilation in cataract patients. Methodology: A prospective observational study was conducted, and comprehensive literature was studied on comparing the mydriatic effect between Tropicamide with Phenylephrine and Flurbiprofen vs. tropicamide and phenylephrine in cataract patients over 6 months (July 2023–December 2023). A total of 18 subjects were recruited for our study and were administered tropicamide and phenylephrine with urbiprofen, tropicamide, and phenylephrine. Results were recorded by comparing both drugs for pupilar dilation and sustainability. Results: Among 128 patients (age range 20-79 years), 64 were randomized into the tropicamide with phenylephrine and urbiprofen group and 64 into the tropicamide with phenylephrine drug group. baseline pupil sizes were in the range of 2-2.5mm in both groups the mean pupil size at 60min were 6.6mm and 6.5mm in the tropicamide with phenylephrine and urbiprofen and tropicamide with phenylephrine drug groups, respectively. the mean sustainability was 5.2 hours and 4.2 hours in the tropicamide with phenylephrine and urbiprofen group and tropicamide with phenylephrine group. Conclusion: It has been concluded that the combination of 0.03% urbiprofen, 5% phenylephrine, and 0.5% tropicamide is more effective for the dilatation of the pupils than using only 5% phenylephrine and 0.5% tropicamide. This combination produces quicker results within 60 minutes.