New Flavan Derivatives from the Leaves and Stems of Cassia nodosa

Three new flavan derivatives including two methylene‐linked flavan‐3‐ol dimers, bis (8‐epiafzelechinyl)methane ( 1 ), and 8,8‐(epiafzelechin‐afzelechin)methane ( 2 ), a flavan‐3‐ol monomer, (−)‐3‐ O ‐acetyl‐epiafzelechin ( 3 ) and four known related compounds ( 4 – 7 ) were isolated from the leaves and stems of Cassia nodosa . Their structures were elucidated by extensive spectroscopic analyses and CD data. The isolates were evaluated for their antioxidant, α ‐glucosidase inhibitory, cytotoxic and neuroinflammatory activities, and compound 3 exhibited remarkable radical scavenging activities in both the DPPH and ABTS models with IC 50 values of 2.65±1.25, and 4.78±0.91 μ g/mL, respectively.