Supplementary Figure S1 from Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium

A, Binding curves determined by SPR of 6-3-A6 and E7011 to murine and cynomolgus monkey Notch4. B, Binding of 6-3-A6 and E7011 at increasing concentrations to transfected HEK293 cell lines overexpressing full length human, murine, and cynomolgus Notch4 as assessed by mean fluorescent intensity (MFI) using flow cytometry.