Preclinical Evaluation of Hydro-Alcoholic Extract of Hygrophila Auriculata Leaves for Cardio-Tropic Activity

Aim of the present study was to evaluate the cardio tropic activity of hydro-alcoholic extract of Hygrophila auriculata leaves on Albino wistar rat.In this study the leaves of Hygrophila auriculta were subjected to cold percolation extraction by using 70% ethanol for 48 hours and 6.57% yield was obtained.The presence of various phytochemical constituents like alkaloid, carbohydrate, cardiac glycoside, tannin, saponin, flavonoid and protein were found by phytochemical investigation of the extract.Albino wistar rats weighing around 100-120 g were used in this study.Different doses of acetylcholine, adrenaline and hydro-alcoholic extract of Hygrophila auriculata leaves were given on heart of the experimental animals.The cardio tonic response supports the traditional use of Hygrophila auriculata in the treatment of heart failure.Due to the presence of cardiac glycoside, Hygrophila auriculata has produced cardio tonic effect and may be effective in the treatment of heart failure.This finding establishes the traditional use of Hygrophila auriculata in heart failure.