Psoriasis pathogenesis: What’s new in angiogenesis and angiopoietins

Psoriasis is a common chronic inflammatory skin disorder primarily characterized by scaly, erythematous plaques. Microvascular abnormalities are a major pathogenic mechanism, with early histological changes including tortuous dilation of capillaries in the papillary dermis. Increased vascular permeability and angiogenesis nourish proliferative keratinocytes, facilitate inflammatory cell migration, and significantly contribute to the onset and persistence of psoriasis. Angiopoietins, a class of proangiogenic factors, play a significant role in regulating vascular stability, angiogenesis under physiological and pathological conditions, and inflammatory processes. This paper provides a comprehensive review of the advancements in our understanding of angiogenesis and the role of angiopoietins in the context of psoriasis.