Objective: To investigate the impact of aerobic exercise on nitric oxide (NO) signal transduction and related cytokines in ApoE-/- mice and its underlying mechanisms. Methods: ApoE-/- mice were divided into a control group and an aerobic exercise group. An 8-week aerobic exercise intervention using a treadmill training model was conducted to determine the expression levels of NO signal transduction-related cytokines. Results: Aerobic exercise significantly increased the expression of NO and related cytokines in the plasma of ApoE-/- mice and reduced the level of inflammatory factors. Conclusion: Aerobic exercise can enhance NO signal transduction, reduce inflammatory responses, and improve the cardiovascular function of ApoE-/- mice.
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Song et al. (2024) studied this question.
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