Key result
Voluntary exercise significantly reduced the area of atherosclerotic lesions in the aortic sinus (7.2% vs 19.9%) and thoracoabdominal aorta (18.6% vs 31.6%) in ApoE-deficient mice fed a high-fat diet.
Why the study?
Does voluntary exercise reduce atherosclerotic lesion formation in ApoE-deficient mice fed a high-fat diet?
Does voluntary exercise reduce atherosclerotic lesion formation in ApoE-deficient mice fed a high-fat diet?
Absolute Event Rate: 7.2% vs 19.9%
p-value: p=<0.001
Voluntary exercise reduces atherosclerotic lesion progression and endothelial dysfunction in ApoE-deficient mice on a high-fat diet, likely through anti-inflammatory mechanisms including increased adiponectin.
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Supports mechanistic studies of exercise in atherosclerosis models; leaves open translation to human prevention strategies.
Fukao et al. (2010) studied Atherosclerosis (n=24). Voluntary exercise vs. Sedentary (no exercise) was evaluated on Percent area of atherosclerotic lesion formation in the aortic sinus (p=<0.001). Voluntary exercise significantly reduced the area of atherosclerotic lesions in the aortic sinus (7.2% vs 19.9%) and thoracoabdominal aorta (18.6% vs 31.6%) in ApoE-deficient mice fed a high-fat diet.
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