cUMP elicits inter-endothelial gap formation during Pseudomonas aeruginosa infection

A. Deweever; Sunita S. Paudel; Chun Zhou; C. Michael Francis; Dhananjay T. Tambe; Dara W. Frank; Ron Balczon; Troy Stevens

doi:10.1152/ajplung.00164.2023

July 30, 2024AJP Lung Cellular and Molecular PhysiologyOpen Access

cUMP elicits inter-endothelial gap formation during Pseudomonas aeruginosa infection

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Key Points

During Pseudomonas aeruginosa infection, bacterial ExoY generates cUMP to elicit inter-endothelial gap formation while impairing cell motility and growth.
Cellular analysis shows that the nucleotidyl cyclase ExoY undergoes activation by filamentous actin, which promotes synthesis of cyclic nucleotides.
Uncovering cUMP-driven endothelial disruption highlights a distinct pathogenic mechanism; cell culture model; further preclinical work is needed.

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Implication

In vitro study reveals ExoY-generated cUMP drives inter-endothelial gap formation in host cells, highlighting a novel mechanism of bacterial barrier disruption.

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Cite This Study

Deweever et al. (2024) studied this question.

synapsesocial.com/papers/68e5e8eeb6db64358757d5e7 https://doi.org/10.1152/ajplung.00164.2023

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cUMP elicits inter-endothelial gap formation during Pseudomonas aeruginosa infection

Key Points

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Implication

Discussion

Cite This Study

cUMP elicits inter-endothelial gap formation during Pseudomonas aeruginosa infection

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

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