Neutrophil Activation and Maternal Plasma Exosomal miR-301b-3p Decrease in Patients with Preeclampsia

Background: To evaluate the diagnostic value of circulating plasma exosomal miR-301b-3p and neutrophils (NE#) for preeclampsia (PE). Methods: The study cohort consisted of pregnant women with Hypertensive disorders of pregnancy (HDP) who were selected from Guangdong Women and Children Hospital between January 2017 and November 2017. A total of 80 cases with gestational hypertension (GH n=31) and preeclampsia (PE n=49) were chosen at random for each group. Furthermore, a group of healthy pregnant women was chosen as the control group (Control n=83). Quantitative reverse-transcription PCR (qRT-PCR) was used to detect the relative expression of miR-301b-3p in exosomes found in maternal plasma. Results: The antenatal Control group had higher miR-301b-3p expression levels than the GH and PE groups (P <0.05). The ROC curve analysis indicates a predictive value for case groups (P <0.05). The Pearson correlation analysis indicates an inverse correlation between miR-301b-3p levels and illness severity in pathological patients (P <0.05). Conclusion: miR-301b-3p is closely associated with the severity of vascular inflammation in PE.