Preclinical study reveals enhanced regulatory T cell infiltration in hepatocellular carcinoma syngeneic models, highlighting SOX12 as a promoter of tumor immunosuppression.
Despite the success of immunotherapy in treating hepatocellular carcinoma (HCC), HCC remains a severe threat to health. Here, a crucial transcription factor, SOX12, is revealed that induces the immunosuppression of liver tumor microenvironment. Overexpressing SOX12 in HCC syngeneic models increases intratumoral regulatory T-cell (Treg) infiltration, decreases CD8
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Luo et al. (2024) studied this question.
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