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July 29, 2024HistopathologyOpen Access

Retained PAX2 expression associated with DNA mismatch repair deficiency in endometrial endometrioid adenocarcinoma

Gloria Zhang Bin Yang

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Abstract

Loss of expression of tumour suppressor PAX2 and MMR deficiency (dMMR) has been frequently seen in endometrial endometrioid adenocarcinoma (EEC). However, the relationship between PAX2 expression and MMR status is unknown.

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Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e5ea48b6db64358757f5c4 https://doi.org/10.1111/his.15281

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1<scp> <i>PAX2</i> </scp> is regulated by estrogen/progesterone through promoter methylation in endometrioid adenocarcinoma and has an important role in carcinogenesis via the <scp>AKT</scp> / <scp>mTOR</scp> signaling pathwayOriginal Research · 2024 · 7 citations
2Mismatch Repair (MMR) Protein Deficiency in Endometrioid Endometrial Carcinoma: Is There a Survival Impact?Original Research · 2026
3PAX2 is Transcriptionally Silenced by a Distinct Mechanism of Epigenetic Reprogramming to Initiate Endometrial CarcinogenesisOriginal Research · 2024
4Identifying the frequency of mismatch repair deficiency in endometrial carcinoma in a tertiary care hospital2024
5971 Mismatch-repair deficiency is associated with a higher risk of recurrence than no specific molecular profile in early-stage endometrial cancer2024

More related papers

A distinct mechanism of epigenetic reprogramming silences PAX2 and initiates endometrial carcinogenesis2025
Clinicopathological Implications of Mismatch Repair Status in Endometrioid Endometrial Cancer in Duhok City2024
Treatment Option for Deficient Mismatch Repair (dMMR) and Proficient Mismatch Repair (pMMR) in Endometrial Cancer2026

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