Epigenetic Regulation of Angiogenesis and Its Intervention by Traditional Chinese Medicine

Neovascularization refers to the generation of new blood vessels from the existing vascular system, which occurs in the development of various tissues and organs and in the repair of injuries, and is mainly dependent on a variety of growth factors and hypoxia-induced, and plays an important role in the complex molecular mechanisms of the development of many diseases, including tumors, diabetes mellitus, inflammation, chronic liver disease, cardiac disease, and degenerative eye disease, etc., and the inhibition or promotion of neovascularization has emerged as a potential strategy for the treatment of these diseases Inhibition or promotion of neovascularization is one of the potential strategies for the treatment of these diseases. Epigenetic inheritance refers to changes in gene expression or cellular phenotypes in which genetic information occurs through certain mechanisms or pathways that can be preserved and passed on to offspring without altering the DNA sequence. In recent years, epigenetics has played an increasingly important role in the study of angiogenesis and is involved in the normal regulation of many angiogenic pathways and disease-related abnormal processes. This review explores how epigenetics affects different aspects of angiogenesis and its treatment by Chinese medicine interventions, in order to better understand the mechanisms of disease onset and progression, and to provide new ideas for disease prevention and treatment as well as drug development.