Thyroid cancers stand out as the most prevalent among endocrine system malignancies, contributing to about 3.4% of all diagnosed cancers worldwide1. A distinct type within this category is medullary thyroid cancer, originating from parafollicular C cells traced back to neural crest origins. Upon microscopic examination of these cells, a unique amyloid backdrop becomes evident. These tumors have the intriguing ability to generate a range of substances, including calcitonin, carcinoembryonic antigen, serotonin, and chromogranin2. While around 75% of cases arise sporadically, the remaining 25% are tied to familial factors. Sporadic instances can emerge at any age, whereas the hereditary form tends to affect children and young adults, giving the disease a multifaceted demographic3.
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Ali et al. (2024) studied this question.
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