July 27, 2024British Journal of Pharmacology

IDH2‐NADPH pathway protects against acute pancreatitis via suppressing acinar cell ferroptosis

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Authors

PQPeng QiXinyang Normal University БЛБин ЛиWenzhou University PSPengli SongShanghai Jiao Tong University

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Implication

Experimental study reveals that activating the IDH2-NADPH pathway suppresses acinar cell ferroptosis in mice, highlighting a potential therapeutic approach for acute pancreatitis.

Key Points

Inhibition of acinar cell ferroptosis attenuates lipid peroxidation and mitochondrial damage, reducing overall tissue injury during experimental acute pancreatitis.
Metabolomics and genetic deletion in murine models mapped metabolic shifts in pancreatic acinar cells, tracking caerulein-induced injury and tricarboxylic acid cycle changes.
Highlights IDH2-dependent pathways and coq10 as viable therapeutic strategies against acute pancreatitis via ferroptosis suppression—mouse model; further preclinical work needed.

Cite This Study

Qi et al. (2024) studied this question.

synapsesocial.com/papers/68e5ec4fb6db6435875819b3 https://doi.org/10.1111/bph.16469

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Implication

Experimental study reveals that activating the IDH2-NADPH pathway suppresses acinar cell ferroptosis in mice, highlighting a potential therapeutic approach for acute pancreatitis.

IDH2‐NADPH pathway protects against acute pancreatitis via suppressing acinar cell ferroptosis

Discussion

Member takes

Implication

Key Points

Cite This Study

IDH2‐NADPH pathway protects against acute pancreatitis via suppressing acinar cell ferroptosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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