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July 27, 2024Clinical and Translational Radiation OncologyOpen Access

Radiation response assessment of organoids derived from patients with pancreatic cancer

Iris W.J.M. van Goor Léon Raymakers Daan Andel Lodewijk A.A. Brosens Onno Kranenburg Jeanette H.W. Leusen Gert J. Meijer I. Quintus Molenaar Hjalmar C. van Santvoort J.H.W. De Vries Andre J.M. Wopereis Martijn Intven Lois A. Daamen

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Abstract

The effectiveness of radiotherapy for pancreatic cancer is debated. Patient-derived organoids (PDOs) already mimicked clinical radiation response in other cancer types, which could be valuable in pancreatic cancer as well. This study aimed to investigate whether PDOs can be used to model RT response in pancreatic cancer and to explore the presence of a dose-response correlation.

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Cite This Study

Goor et al. (2024) studied this question.

synapsesocial.com/papers/68e5ed47b6db643587581c73 https://doi.org/10.1016/j.ctro.2024.100829

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