In this paper, a direct access to benzylic amines from in‐situ generated ortho ‐quinone methides ( o ‐QMs) and isocyanate/isothiocyanate via decarboxylation is described. This base‐catalyzed methodology has high functional group tolerance and shows a wide range of substrate scopes, where H 2 O as a nucleophile for isocyanate/isothiocyanate for product formation. The products are insensitive to air and moisture, which makes this synthetic strategy more efficient for the construction of various benzyl amine derivatives.
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Sahoo et al. (2024) studied this question.
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