Cardioneuroablation: A novel application for the treatment of severe mixed-pattern vasovagal syncope and orthostatic tachycardia without cardioinhibition—A case report

Vasovagal syncope (VVS), presents significant management challengeswhen conservative and pharmacological treatments have failed. This case study examines the efficacy of cardioneuroablation, a precise autonomic modulation technique targeting cardiac ganglia, in a notably complex case of VVS unresponsive to standard lifestyle and pharmacological interventions with diminished . This case report highlights the incompletely-understood nuanced mechanisms through which cardioneuroablation can modulate autonomic effects, both in abolishing the vagal reflex, but also in mitigating the tachycardia response to head up tilt, likely through a combination of efferent and afferent autonomic effects.