Intraperitoneal Administration of 17-DMAG as an Effective Treatment against Leishmania braziliensis Infection in BALB/c Mice: A Preclinical Study

Kercia Pinheiro Cruz; Antonio L. O. A. Petersen; Marina F. Amorim; Alan G. S. F. Pinho; Luana C. Palma; Diana A. S. Dantas; Mariana R. G. Silveira; Carine S. A. Silva; Ana Luiza J. Cordeiro; Izabella G. Oliveira; Gabriella B. Pita; Bianca C. A. Souza; Gilberto Cafezeiro Bomfim; Cláudia I. Brodskyn; Deborah Bittencourt Mothé Fraga; Isadora dos Santos Lima; Maria Borges Rabêlo de Santana; Helena Mariana Pitangueira Teixeira; Juliana Perrone Bezerra de Menezes; Washington L. C. dos‐Santos; Patrícia Sampaio Tavares Veras

doi:10.3390/pathogens13080630

Key Points

Intraperitoneal administration of 17-DMAG serves as an effective therapeutic intervention against Leishmania braziliensis infection in murine hosts.
Preclinical evaluation in BALB/c mice assessed systemic delivery of 17-DMAG against parasite burden and infection progression across experimental cohorts.
Therapeutic efficacy supports further development of 17-DMAG against leishmaniasis, though findings are confined to a BALB/c mouse model needing validation.

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Implication

Preclinical study demonstrates that intraperitoneal 17-DMAG treats Leishmania braziliensis infection in BALB/c mice, highlighting potential therapeutic value against leishmaniasis.

Abstract

Leishmaniasis is a significant global public health issue that is caused by parasites from

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Cruz et al. (2024) studied this question.

synapsesocial.com/papers/68e5ed4cb6db643587581eb9 https://doi.org/10.3390/pathogens13080630

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Intraperitoneal Administration of 17-DMAG as an Effective Treatment against Leishmania braziliensis Infection in BALB/c Mice: A Preclinical Study

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Intraperitoneal Administration of 17-DMAG as an Effective Treatment against Leishmania braziliensis Infection in BALB/c Mice: A Preclinical Study

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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