Stevens-Johnson syndrome due to Lamotrigine

Lamotrigine is an anticonvulsant drug that has been widely used to treat epilepsy, as a mood stabilizer (in cases of bipolar type 1 disorder), and in the management of neuropathic pain; It is used both in monotherapy and in complementary therapy. Considered a relatively new medication, approved by the Food and Drug Administration in 1994, its benefits include a greater margin of safety compared to other anticonvulsants; However, it causes serious adverse skin reactions, such as Stevens-Johnson syndrome. Approximately 8% of patients receiving lamotrigine develop a benign maculopapular rash during the first 4 months of treatment. A case of Stevens-Johnson syndrome caused by the drug is presented and a review of the condition and the probable pathways that trigger this delayed hypersensitivity immune response is carried out.