Lamotrigine-induced Stevens–Johnson syndrome: a systematic review of case reports and case series

Ankita Saxena; Vaibhav Chaudhary; Sweta Kumari; Md. Majibul Haque Babu; N. H. Siddiqui; Rishikesh Kumar; Krishna Pandey; Arun Kumar Jha; K K Sharma; Biplab Pal

doi:10.1080/15563650.2026.2634767

March 17, 2026Clinical Toxicology

Lamotrigine-induced Stevens–Johnson syndrome: a systematic review of case reports and case series

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Key Points

This review aims to compile cases of Stevens-Johnson syndrome linked to lamotrigine to assess risks and improve safety protocols.
Conducted a systematic review of existing case reports and series.
Analyzed data on lamotrigine dosages, symptom onset, and patient outcomes.
Evaluated the need for standardized reporting and causality assessment.
Identified multiple cases of Stevens-Johnson syndrome associated with lamotrigine use.
Early recognition and careful dosage adjustment were crucial in preventing severe outcomes.
Calls for improved education and reporting practices to ensure patient safety.

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Implication

Systematic review highlights serious reactions to lamotrigine in patients, emphasizing safer prescribing practices.

Abstract

Lamotrigine-induced Stevens-Johnson syndrome is a rare but serious reaction. Careful dose titration, early recognition of symptoms, and patient education are imperative. Standardized reporting and causality assessment are needed to strengthen the evidence base and support safer prescribing.

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Cite This Study

Saxena et al. (2026) studied this question.

synapsesocial.com/papers/69be35166e48c4981c6733d2 https://doi.org/10.1080/15563650.2026.2634767

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Lamotrigine-induced Stevens–Johnson syndrome: a systematic review of case reports and case series

Key Points

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Implication

Abstract

Discussion

Cite This Study

Lamotrigine-induced Stevens–Johnson syndrome: a systematic review of case reports and case series

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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