Effect of Adding Luteinizing Hormone (lh) activity during Controlled Ovarian Hyperstim ulation (coh) by adding Human Chorionic Gonadotropin vs. Low Dosage Human Chorionic Gonadotropin on Subsequent Pregnancy Rates Following Frozen Embryo Transfer

There are some studies suggesting that the addition of luteinizing hormone (LH) activity to follicle stimulating hormone (FSH) stimulation for controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF) may increase the live delivered pregnancy rates (LDPRs). The study presented herein was not designed to prove or disprove the concept of whether adding LH activity does or does not improve the LDPRs, but instead to determine if LH activity is needed is it better to add human menopausal gonadotropins (hMG) to add LH activity or just use low dosage human chorionic gonadotropin (hCG) injections added to FSH stimulation. The latter is less expensive. To determine if one agent is superior to the other whether the benefit is related to creating better embryos or not. The study used frozen embryo transfer (ET) cycles so that an effect on the endometrium itself would be eliminated since the cycle of evaluation would be the next cycle after COH with just a graduated estrogen regimen followed by progesterone (P). The results showed no advantage of the more costly use of hMG vs. low-dose hMG.