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July 26, 2024ACS Central ScienceOpen Access

Protein Complex Heterogeneity and Topology Revealed by Electron Capture Charge Reduction and Surface Induced Dissociation

Jared Shaw Sophie R. Harvey Chen Du Zhixin Xu Regina M. Edgington Eduardo Olmedillas Erica Ollmann Saphire Vicki H. Wysocki

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Abstract

We illustrate the utility of native mass spectrometry (nMS) combined with a fast, tunable gas-phase charge reduction, electron capture charge reduction (ECCR), for the characterization of protein complex topology and glycoprotein heterogeneity. ECCR efficiently reduces the charge states of tetradecameric GroEL, illustrating Orbitrap

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Cite This Study

Shaw et al. (2024) studied this question.

synapsesocial.com/papers/68e5ed5ab6db6435875828fc https://doi.org/10.1021/acscentsci.4c00461

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