Cocaine is a highly addictive substance and represents a significant public health concern. The incidence of cocaine-associated myocardial infarction is low (4.7%). Coronary spasm is the presumed etiology as most patients have normal coronary arteries. We report a case of a 31-years old patient with known history of cocaine abuse that presented an acute thrombosis of the left anterior descending by a large intra-coronary thrombus. There are no specific guidelines about treating thrombus formation in coronary arteries due to cocaine use. Thereby, an optimal anti-thrombotic alone remains an effective alternative, As reported in our case, with a complete thrombus resolution.
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