Subhypnotic doses of Propofol for Nausea and Vomiting

The second most frequent postoperative complication following wound infection is postoperative nausea and vomiting. Retching and vomiting can cause a wound to dehisce, extending hospital stays and increasing costs. Numerous clinical studies have revealed that propofol is equally efficient at lowering the incidence of nausea and vomiting after intrathecal morphine administration as it is at reducing pruritus. Aim: The aim of the study was to analyse the antiemetic effects of sub hypnotic dose of propofol in various surgical conditions. Methods: An extensive research of all materials related to the topic was carried out in the PubMed and Google scholar search engine .relevant research articles focusing on sub hypnotic doses of Propofol for nausea and vomiting published since 2019 were included in the review .several review articles were excluded, and studies related to anaesthesia were included from 241articles, narrowing it down to a total of 7 studies which implies the subhypnotic doses of the drug in various anaesthesia related clinical scenarios. A total of 7 studies similar to the current study objectives were included in the study and analyzed. keywords used in the searches included Propofol, sub hypnotic, nausea, vomiting. Conclusion: Sub hypnotic dose of Propofol (0.5mg-1.0mg/kg/hr) given pre operatively effectively reduce post-operative nausea and vomiting in various surgical operation. But the duration of its anti-emetic effect seems to be lower than other anti-emetic drugs in the market. Still it can be effectively used in reducing post op and intra op nausea and vomiting.