July 23, 2024Hypertension

Comparing ARR Versus Suppressed PRA as Screening Tests for Primary Aldosteronism

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Authors

MMMarco MarcelliQuest Diagnostics (United States)CBCaixia BiQuest Diagnostics (United Kingdom)JFJohn W. FunderHudson Institute

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Implication

Comparative assessment reports high variability in aldosterone-to-renin ratio screening for primary aldosteronism, highlighting suppressed plasma renin activity as a potential alternative.

Key Points

Aldosterone-to-renin ratio screening for primary aldosteronism displays notable variability across expert centers and repeated tests in the same individual.
Comparative assessment examines plasma renin activity and plasma aldosterone concentration draws, identifying a suppressed renin cutoff under 1 ng/mL per h as an alternative test.
Evaluating suppressed plasma renin activity instead of ratio-based tests may overcome inter-center assay discrepancies and improve diagnostic consistency for primary aldosteronism.

Cite This Study

Marcelli et al. (2024) studied this question.

synapsesocial.com/papers/68e5f50bb6db643587589a71 https://doi.org/10.1161/hypertensionaha.124.22884

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Implication

Comparative assessment reports high variability in aldosterone-to-renin ratio screening for primary aldosteronism, highlighting suppressed plasma renin activity as a potential alternative.

Comparing ARR Versus Suppressed PRA as Screening Tests for Primary Aldosteronism

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparing ARR Versus Suppressed PRA as Screening Tests for Primary Aldosteronism

Discussion

Member takes

Implication

Key Points

Cite This Study

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Also Consider