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July 23, 2024The Journal of Organic Chemistry

Biocatalytic Stereoselective Synthesis of Chiral Precursors for Liposoluble β₁ Receptor Blocker Nebivolol

Jia‐Yu Xue Zhe Dou Zewen Sun Tianwei Luo Xiaoyu Chen Ye Ni Guochao Xu

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Abstract

Asymmetric reduction of 2-chloro-1-(6-fluorochroman-2-yl)ethan-1-one (NEB-7) into 2-chloro-1-(6-fluorochroman-2-yl)ethan-1-ol (NEB-8) is the crucial step for synthesis of liposoluble β

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Cite This Study

Xue et al. (2024) studied this question.

synapsesocial.com/papers/68e5f61cb6db64358758a083 https://doi.org/10.1021/acs.joc.4c01027

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