TP53 Arg72Pro polymorphism and its relationship with major depressive disorder

This study investigates the association between the TP53 Arg72Pro polymorphism and major depressive disorder (MDD) using a case-control approach. The study sample comprised 97 individuals: 16 in the case group diagnosed with MDD and 81 in the control group. Genotyping was conducted using the PCR-RFLP technique, with the genotypic frequencies calculated by direct counting and statistical significance at 5% (P<0.05). Results indicated that the TP53 Arg72Pro polymorphism's Pro allele was significantly more frequent in the MDD case group. These findings suggest that the Pro allele is associated with an increased risk of developing major depressive disorder.