What question did this study set out to answer?

To evaluate the influence of the TP53 Arg72Pro (rs1042522) polymorphism on therapeutic response and survival outcomes in patients with cervical cancer receiving chemoradiotherapy.

March 26, 2018Oncology LettersOpen Access

TP53 Arg72Pro polymorphism is associated with increased overall survival but not response to therapy in Portuguese/Caucasian patients with advanced cervical cancer

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Authors

ACAna CoelhoFernando Pessoa University ANAugusto NogueiraInstituto Português de Oncologia de Coimbra Francisco Gentil SSSílvia SoaresFernando Pessoa University

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Implication

Retrospective cohort study reveals increased overall survival linked to TP53 Arg/Pro genotype in advanced cervical cancer, highlighting potential benefits of pharmacogenomic profiling.

Key Points

To evaluate the influence of the TP53 Arg72Pro (rs1042522) polymorphism on therapeutic response and survival outcomes in patients with cervical cancer receiving chemoradiotherapy.
Conducted a hospital-based retrospective cohort study of 260 Caucasian patients diagnosed with cervical cancer and treated with concomitant radiotherapy and chemotherapy.
Genotyped the TP53 Arg72Pro polymorphism using allelic discrimination by quantitative polymerase chain reaction.
Patients carrying the heterozygous Arg/Pro genotype experienced significantly longer median overall survival compared to those with Arg/Arg and Pro/Pro genotypes (126 months vs. 111 months; P=0.047).
The TP53 Arg72Pro polymorphism showed no significant association with response to therapy (P=0.571) or disease-free survival (P=0.081).

Cite This Study

Coelho et al. (2018) studied this question.

synapsesocial.com/papers/6a0d641a6e03bc61cb09bc17 https://doi.org/10.3892/ol.2018.8354

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Implication

Retrospective cohort study reveals increased overall survival linked to TP53 Arg/Pro genotype in advanced cervical cancer, highlighting potential benefits of pharmacogenomic profiling.

TP53 Arg72Pro polymorphism is associated with increased overall survival but not response to therapy in Portuguese/Caucasian patients with advanced cervical cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

TP53 Arg72Pro polymorphism is associated with increased overall survival but not response to therapy in Portuguese/Caucasian patients with advanced cervical cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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