Critical Review of Pharmaceutical, Analytical and Toxicity Characterization of Pittala Bhasma

India has long utilized Brass, also known as Pittala, as a remedy for a range of ailments. The two elementary steps in the preparation of Pittala Bhasma (PB) are Shodhana (detoxification) and Marana (controlled incineration). The current study aims to gather and evaluate all pertinent and standard work that has been done on PB preparation, as well as standardize it concerning its safety, analytical, and pharmaceutical parameters. It is necessary to detect and quantify these drugs because they can accumulate contaminants during multiple stages of manufacturing, transportation, and storage, which can make them dangerous to use. In this regard, analytical instruments and methods are crucial. Advanced analytical techniques such as energy-dispersive X-ray, Fourier-transform infrared, scanning electron microscopy, transmission electron microscope, and X-ray diffraction may expand our comprehension of drugs' overall effects on the body, including their structure, behavior, and response. The preparation of PB involved a thorough search of relevant ancient Indian literature on ayurvedic pharmaceuticals as well as modern research databases like Scopus and PubMed and other relevant online content. This research may shed illumination on its possible application in characterization and therapeutics, eventually enhancing human life.