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July 22, 2024Cell CalciumOpen Access

Interstitial cell of Cajal-like cells (ICC-LC) exhibit dynamic spontaneous activity but are not functionally innervated in mouse urethra

Neha Gupta Salah A. Baker Kenton M. Sanders Caoimhín S. Griffin Gerard P. Sergeant Mark A. Hollywood K. D. Thornbury Bernard T. Drumm

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Abstract

Urethral smooth muscle cells (USMC) contract to occlude the internal urethral sphincter during bladder filling. Interstitial cells also exist in urethral smooth muscles and are hypothesized to influence USMC behaviours and neural responses. These cells are similar to Kit

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Gupta et al. (2024) studied this question.

synapsesocial.com/papers/68e5f842b6db64358758bf29 https://doi.org/10.1016/j.ceca.2024.102931

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle2024 · 9 citations
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5Spontaneous electrical and Ca<sup>2+</sup>signals in typical and atypical smooth muscle cells and interstitial cell of Cajal‐like cells of mouse renal pelvispreclinical · 2007 · 66 citations