Key result
Vimentin-positive, c-kit-negative interstitial-like cells were identified in human and rat myometrium, exhibiting a resting membrane potential of -58+/-7 mV and lacking inward currents.
Population
Freshly dispersed uterine muscle strips from pregnant human and rat myometrium and in situ uterine…
Comparison
Morphological, ultrastructural… vs Uterine myocytes (smooth-muscle cells)
Design
Preclinical
Authors
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May inhibit myometrial activity; hypothesis-generating for uterine disorders and requires functional validation.
This study provides the first description of vimentin-positive, c-kit-negative ICC-like cells in human and rat myometrium, suggesting a possible role as inhibitors of intrinsic smooth-muscle activity.
Duquette et al. (2004) studied Pregnant human and rat myometrium. Vimentin-Positive, c-KIT-Negative Interstitial Cells (ICC-like cells) vs. Uterine myocytes was evaluated on Cell morphology, ultrastructure, and electrophysiological properties. Vimentin-positive, c-kit-negative interstitial-like cells were identified in human and rat myometrium, exhibiting a resting membrane potential of -58+/-7 mV and lacking inward currents.
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