Preclinical analysis demonstrates porphyrin accumulation in the tumor microenvironment, suggesting dysregulation of heme biosynthesis and mid-step gene dependence.
Heme, an iron-containing tetrapyrrole, is essential in almost all organisms. Heme biosynthesis needs to be precisely regulated particularly given the potential cytotoxicity of protoporphyrin IX, the intermediate preceding heme formation. Here, we report on the porphyrin intermediate accumulation within the tumor microenvironment (TME), which we propose to result from dysregulation of heme biosynthesis concomitant with an enhanced cancer survival dependence on mid-step genes, a process we recently termed "
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Adapa et al. (2024) studied this question.
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