A genealogy-based single-cell transcriptome analysis was performed for the first 10 cells in the early embryogenesis in Caenorhabditis elegans. Transcriptome differences were observed between all compared mother-daughter and sibling pairs and were also seen for the same cells at different reproductive ages. It is hoped that this unconventional way of analyzing transcriptome profiles will lead to a better understanding of the contribution of intrinsic asymmetry in cell reproduction to cell differentiation and cell fate determination in multicellular development.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: