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July 22, 2024Frontiers in Chemical BiologyOpen Access

Generation and preclinical evaluation of a human heavy-chain-only antibody recognizing the membrane-bound tumor-associated antigen mesothelin

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Authors

RJRick JanssensErasmus MC RHRien van HaperenErasmus MC MRMichael van der ReijdenErasmus MC

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Janssens et al. (2024) studied this question.

synapsesocial.com/papers/68e5f853b6db64358758c8ee https://doi.org/10.3389/fchbi.2024.1408621

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Data from A Bispecific Antibody That Targets the Membrane-Proximal Region of Mesothelin and Retains High Anticancer Activity in the Presence of Shed Mesothelin2024
2A Bispecific Antibody That Targets the Membrane-Proximal Region of Mesothelin and Retains High Anticancer Activity in the Presence of Shed Mesothelin2024 · 12 citations
3Abstract 2633: A T-cell engager antibody targeting the non-shed site of mesothelin in solid tumors.2026
4JNJ-79032421, a Novel Membrane-restricted Mesothelin-targeting T-cell-engaging Bispecific Antibody for the Treatment of Mesothelin-positive Cancers.2026
5Computational modeling and experimental validation of the interaction between tumor biomarker mesothelin and an engineered targeting protein with therapeutic activity.2025