Theoretical report demonstrates dynamic regulation of electron transfer in mitochondria by ADP and ATP, highlighting how feedback mechanisms govern respiration.
Very often, we present metabolic cycles schematically, i.e. we limit ourselves only to listing precursors, intermediates and end products of metabolism. Meanwhile, it is now well known that poly-enzyme systems have the ability to self-regulate, which is the result of the specific organization of the sequence of reactions, the specific properties of individual enzymes of the system, as well as the action of feedback mechanisms and other types of inhibition. In this report, we will consider the dynamics of electron transfer in mitochondria and its regulation by ADP and ATP
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Elizaveta I Bon (2024) studied this question.
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