Population
Theoretical semi-quantitative control-analysis model of energy metabolism (glycolysis)
Design
Preclinical
Authors
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Should not alter cardiovascular practice; extends theoretical models of metabolic control but leaves translation open.
Theoretical modeling suggests that physiological ATP demand (ATPase activation) can exert primary control over glycolytic flux while maintaining excellent metabolite homeostasis, highlighting the importance of known effector interactions like ADP inhibition of ATPase and AMP activation of PFK.
Thomas et al. (1998) studied this question.
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