Key result
The each-step-activation mechanism allows maintenance of a high degree of control exerted by ATP usage over ATP turnover and oxygen consumption flux even at high energy demands.
Population
Computer model of oxidative phosphorylation in intact oxidative skeletal muscle
Comparison
Simulation of the each-step-activation mechanism vs Simulation in the absence of the…
Design
Preclinical
Authors
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Hypothesis-generating for muscle bioenergetics models; leaves open human cardiac translation pending in vivo validation.
This in silico study demonstrates that the each-step-activation mechanism is crucial for maintaining ATP production and oxygen consumption flux during high energy demands in skeletal muscle.
Liguzinski et al. (2006) studied Intact oxidative skeletal muscle. Each-step-activation mechanism vs. Absence of each-step activation was evaluated on Distribution of control over the oxygen consumption flux. The each-step-activation mechanism allows maintenance of a high degree of control exerted by ATP usage over ATP turnover and oxygen consumption flux even at high energy demands.
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