Key result
Computer simulations suggest that parallel direct activation of actinomyosin-ATPase and oxidative phosphorylation by an external effector is the main mechanism fitting ATP production to consumption.
Population
Dynamic computer model of oxidative phosphorylation during muscle contraction
Comparison
Simulated direct activation of different steps… vs Simulated negative feedback via increase in ADP…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether parallel activation governs ATP matching in human muscle.
Theoretical modeling suggests that parallel direct activation of oxidative phosphorylation and actinomyosin-ATPase by an external effector is the primary mechanism matching ATP supply to demand during muscle contraction.
Bernard Korzeniewski (1998) studied Muscle contraction. Computer simulation of oxidative phosphorylation was evaluated on Changes in respiration rate and ATP/ADP ratio. Computer simulations suggest that parallel direct activation of actinomyosin-ATPase and oxidative phosphorylation by an external effector is the main mechanism fitting ATP production to consumption.
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