Population
Computer models of oxidative phosphorylation regulation during work transitions in skeletal muscle and heart
Comparison
Model B (each-step-activation mechanism) vs Model A (feedback-activation mechanism)
Design
Preclinical
Authors
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No immediate clinical implications; leaves open validation of each-step activation in human OXPHOS regulation.
Theoretical modeling suggests that an 'each-step-activation' mechanism better explains the differences in oxidative phosphorylation regulation between skeletal muscle and intact heart during work transitions.
Bernard Korzeniewski (2013) studied this question.
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