Key result
The transmission of oxygen delivery signals to intracellular metabolic machinery remains debated between traditional diffusion mechanisms and ultrastructural intracellular perfusion models.
Design
Review
Authors
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Myoglobin buffering may favor perfusion over diffusion models; leaves open validation in human cardiac and skeletal muscle.
This review highlights that intracellular oxygen concentrations remain stable during muscle work due to myoglobin buffering, suggesting that oxygen delivery signals are transmitted via intracellular perfusion rather than simple diffusion.
Peter W. Hochachka (1999) conducted a review in Metabolic regulation in skeletal and cardiac muscles. The transmission of oxygen delivery signals to intracellular metabolic machinery remains debated between traditional diffusion mechanisms and ultrastructural intracellular perfusion models.
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