Abstract Continuous local antibiotics perfusion (CLAP), a local drug delivery system, treats bone and soft-tissue infections. CLAP uses continuous negative pressure to deliver appropriate antibiotics concentrations to the infection site. We describe the use of CLAP to treat a deep sternal wound infection (DSWI) due to methicillin-resistant Staphylococcus aureus in an older patient following mitral valve replacement surgery. The procedure was minimally invasive, the inflammatory response resolved rapidly, and sternal wound closure was possible by day 11. Employing CLAP for treating DSWIs offers infection control with relatively minimal invasiveness.
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Shingyouchi et al. (2024) studied this question.
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