Effect of Tripeptide-85 (EVF) on Sebogenesis

Excess skin sebum production has been a concern and could result in oily skin and acne. The cosmetic industry's search for compounds that modulate sebogenesis has been increasing. MC5R is an important regulator of this process. In this work, we report an in silico-designed peptide (Tripeptide-85) that regulates MC5R. We observed that Tripeptide-85 downregulates several sebocyte development and differentiation markers, such as PLIN2, MYC, and SCD, inhibits the formation of lipid droplets in SEBO662AR cells, and reduces sebum production in a clinical randomized, single-blind, placebo-controlled trial. The tripeptide-85 can modulate sebogenesis and can be used alone or as an adjuvant in the management of conditions related to excess sebum production such as acne and oily skin.