Studying the effectiveness of a drug based on Amoxicillin and succinic acid in piglet colibacteriosis

The search for safe and effective medicines with high antibacterial activity is an urgent task. To expand the therapeutic effect combined dosage forms are being developed and implemented. The purpose of our research was to study the effectiveness of a drug based on amoxicillin and succinic acid in piglets with colibacteriosis. To achieve this goal, 45 piglets, two weeks old, of a large white breed, with an average body weight of 5.5 kg at the beginning of the experiment, were selected at a pig breeding enterprise in the Leningrad region. 15 piglets out of 45 were healthy, and 30 piglets had clinical signs of the disease. During the experiment, 3 groups of 15 heads each were formed: the first experimental, the second control and the third intact groups. The first experimental group received the test drug with feed at a dose of 0.0175 g per kg of body weight once a day for 5 days. Animals of the control group (with clinical signs of colibacteriosis) did not receive the drug. The third intact (healthy animals) group served as a reference. After taking the drug based on amoxicillin and succinic acid orally at a dose of 0.0175 g per kg of body weight once a day for 5 days, the piglets of the experimental group had no clinical signs of colibacteriosis, the bacteriological parameters of faecal samples were negative, which can be said about the blood parameters, which returned to normal. At the same time, the animals of the control group had pronounced clinical signs of the disease: asthenia, fever, dehydration, diarrhea, pallor of the mucous membranes, intestinal atony. There were shifts towards deterioration in the biochemical and morphological parameters of the blood, and the result was positive in the laboratory examination of fecal samples. It can be noted that the effectiveness of an antibacterial drug based on amoxicillin and succinic acid is also associated with the fact that succinic acid is included in the composition. Which in turn increases the sensitivity of microorganisms to amoxicillin by increasing the permeability of the bacterial cell membrane, thereby increasing the contact area of the drug with gram-negative and gram-positive microorganisms.